Department of Surgery, Austin Health, Heidelberg, Victoria, Australia
Department of Surgery, Austin Health, Heidelberg, Victoria, Australia.
BMJ Case Rep. 2021 Jun 24;14(6):e242597. doi: 10.1136/bcr-2021-242597.
Castleman's disease (CD) is a rare lymphoproliferative disorder. This case report, to the best of our knowledge, is the first report of CD simulating a pancreatic neuroendocrine tumour . The patient was a 58-year-old woman who initially presented with bilateral iritis and underwent investigation for possible systemic rheumatological disease. CT of the chest demonstrated an incidental finding of a well-demarcated retropancreatic mass. As the mass was found to enhance on DOTATATE (tetraazacyclododecanetetraacetic acid-DPhe1-Tyr3-octreotate) positron emission tomography, a diagnosis of pancreatic neuroendocrine tumour was made. The patient underwent an open distal pancreatectomy and splenectomy. Histopathological examination revealed the unexpected diagnosis of hyaline vascular CD of a lymph node posterior to the pancreas. After 2 years of follow-up, there is no evidence of disease recurrence.
血管滤泡性淋巴结增生症（Castleman's disease，CD）是一种罕见的淋巴组织增生性疾病。据我们所知，本病例报告是首例表现为胰腺神经内分泌肿瘤的 CD。患者为 58 岁女性，最初表现为双侧虹膜炎，并进行了可能的系统性风湿病检查。胸部 CT 显示胰腺后有一个界限清楚的肿块。由于该肿块在 DOTATATE（四氮杂环十二烷四乙酸-DPhe1-Tyr3-奥曲肽）正电子发射断层扫描中增强，因此诊断为胰腺神经内分泌肿瘤。患者接受了开放性胰体尾切除术和脾切除术。组织病理学检查显示出出乎意料的诊断结果，即胰腺后方淋巴结透明血管型 CD。随访 2 年后，无疾病复发迹象。
