Ngoenkam Jatuporn, Paensuwan Pussadee, Wipa Piyamaporn, Schamel Wolfgang W A, Pongcharoen Sutatip
Department of Microbiology and Parasitology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
Department of Optometry, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.
Front Cell Dev Biol. 2021 Jun 8;9:674572. doi: 10.3389/fcell.2021.674572. eCollection 2021.
Signal transduction regulates the proper function of T cells in an immune response. Upon binding to its specific ligand associated with major histocompatibility complex (MHC) molecules on an antigen presenting cell, the T cell receptor (TCR) initiates intracellular signaling that leads to extensive actin polymerization. Wiskott-Aldrich syndrome protein (WASp) is one of the actin nucleation factors that is recruited to TCR microclusters, where it is activated and regulates actin network formation. Here we highlight the research that has focused on WASp-deficient T cells from both human and mice in TCR-mediated signal transduction. We discuss the role of WASp in proximal TCR signaling as well as in the Ras/Rac-MAPK (mitogen-activated protein kinase), PKC (protein kinase C) and Ca-mediated signaling pathways.
信号转导调节免疫反应中T细胞的正常功能。T细胞受体（TCR）与抗原呈递细胞上与主要组织相容性复合体（MHC）分子相关的特异性配体结合后，会启动细胞内信号传导，导致广泛的肌动蛋白聚合。威斯科特-奥尔德里奇综合征蛋白（WASp）是肌动蛋白成核因子之一，它被招募到TCR微簇中，在那里被激活并调节肌动蛋白网络的形成。在这里，我们重点介绍了针对人类和小鼠中WASp缺陷型T细胞在TCR介导的信号转导方面的研究。我们讨论了WASp在近端TCR信号传导以及Ras/Rac-MAPK（丝裂原活化蛋白激酶）、PKC（蛋白激酶C）和钙介导的信号通路中的作用。
