Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
Euro Surveill. 2021 Jun;26(25). doi: 10.2807/1560-7917.ES.2021.26.25.2100507.
To assess the real-world impact of vaccines on COVID-19 related outcomes, we analysed data from over 7 million recipients of at least one COVID-19 vaccine dose in Italy. Taking 0-14 days post-first dose as reference, the SARS-CoV-2 infection risk subsequently decreased, reaching a reduction by 78% (incidence rate ratios (IRR): 0.22; 95% CI: 0.21-0.24) 43-49 days post-first dose. Similarly, hospitalisation and death risks decreased, with 89% (IRR: 0.11; 95% CI: 0.09-0.15) and 93% (IRR: 0.07; 95% CI: 0.04-0.11) reductions 36-42 days post-first dose. Our results support ongoing vaccination campaigns.
为了评估疫苗对 COVID-19 相关结局的真实世界影响，我们分析了意大利超过 700 万名至少接种一剂 COVID-19 疫苗人群的数据。以首剂后 0-14 天为参照，随后 SARS-CoV-2 感染风险降低，第 43-49 天达到 78%的降幅（发病率比（IRR）：0.22；95%CI：0.21-0.24）。同样，住院和死亡风险也降低，第 36-42 天分别降低 89%（IRR：0.11；95%CI：0.09-0.15）和 93%（IRR：0.07；95%CI：0.04-0.11）。我们的结果支持正在进行的疫苗接种运动。
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