抗转移剂DM - COOK的氨基酸衍生物的合成及其抗肿瘤活性
Synthesis and antitumor activity of aminoacid derivatives of the antimetastatic agent DM-COOK.
作者信息
Lassiani L, de Nardo M M, Nisi C, Varnavas A
机构信息
Istituto di Chimica Farmaceutica, Università di Trieste, Italy.
出版信息
Farmaco Sci. 1988 Mar;43(3):227-38.
PMID:3417008
Abstract
Esters and amides of N-(3,3-dimethyl-1-triazeno)benzoylamino acids have been synthesized as inhibitors of cell surface neutral proteases. Preliminary data on activity against P-388 lymphocytic leukemia are also reported.
摘要
已合成了N-(3,3-二甲基-1-三氮烯)苯甲酰基氨基酸的酯类和酰胺类化合物，作为细胞表面中性蛋白酶的抑制剂。还报告了其对P-388淋巴细胞白血病活性的初步数据。
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