1-[(喹诺里西啶基烷基)氨基]-4/7-R-噻吨-9-酮的合成及其抗白血病活性
Synthesis and antileukemic activity of 1-[(quinolizidinylalkyl)amino]4/7-R-thioxanthen-9-ones.
作者信息
Boido Canu C, Iusco G, Boido V, Sparatore F, Sparatore A
机构信息
Istituto di Sicenze Farmaceutiche, Università di Genova, Italy.
出版信息
Farmaco. 1989 Nov;44(11):1069-82.
PMID:2701964
Abstract
Fifteen 1-(quinolizidinylalkyl)amino derivatives of thioxanthenone bearing different substituents on position 4 and 7 were prepared and tested in mice against lymphocytic leukemia P 388. These compounds were inactive or displayed only borderline activity (compounds 1, 10, 15).
摘要
制备了15种在4位和7位带有不同取代基的噻吨酮的1-(喹诺里西啶基烷基)氨基衍生物，并在小鼠身上针对淋巴细胞白血病P 388进行了测试。这些化合物无活性或仅表现出临界活性（化合物1、10、15）。
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