Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.
J Clin Sleep Med. 2021 Dec 1;17(12):2363-2372. doi: 10.5664/jcsm.9436.
Excessive daytime sleepiness (EDS) is a treatment target for many patients with obstructive sleep apnea (OSA). We aimed to understand the prevalence, risk factors, and quality of life associated with EDS in a nonclinical, "real world" sample of patients with OSA.
Cross-sectional survey of patients with OSA participating in an online peer support community, assessing demographics, comorbidities, treatment, and quality of life. Differences in those with and without EDS (Epworth Sleepiness Scale > and ≤ 10) were assessed.
The sample (n = 422) was 54.2% male, 65.9% were ≥ 55 years, and 43.3% reported sleeping ≤ 6 hours/night. EDS was identified among 31.0% of respondents and 51.7% reported sleepiness as a precipitating factor for seeking initial OSA treatment. EDS was more prevalent in individuals reporting asthma, insomnia symptoms, positive airway pressure (PAP) use less than 6 hours/night on ≥ 5 nights/week, or sleep duration < 6 hours/night. After adjusting for demographics and comorbidities, patients with EDS reported poorer mental and physical health and well-being, lower disease-specific functional status, more activity and work impairment, and more driving impairment ( values < .05). In the subsample (n = 265) with high PAP adherence, 26.0% reported EDS, and similar associations between EDS and outcomes were observed.
These "real world" data suggest that patients seeking online OSA support experience a high prevalence of EDS, which was associated with poorer quality of life and worse functional status. Associations persisted among respondents with high self-reported PAP-therapy adherence, potentially driving these individuals to seek online support for sleepiness-related symptoms.
Wanberg LJ, Rottapel RE, Reid ML, et al. Prevalence of sleepiness and associations with quality of life in patients with sleep apnea in an online cohort. . 2021;17(12):2363-2372.
日间嗜睡（EDS）是许多阻塞性睡眠呼吸暂停（OSA）患者的治疗目标。我们旨在了解非临床“真实世界”OSA 患者样本中 EDS 的患病率、危险因素和生活质量。
对参与在线同伴支持社区的 OSA 患者进行横断面调查，评估人口统计学、合并症、治疗和生活质量。评估 EDS 患者（嗜睡量表评分＞和≤10）与无 EDS 患者之间的差异。
该样本（n=422）中 54.2%为男性，65.9%≥55 岁，43.3%报告每晚睡眠时间≤6 小时。31.0%的受访者存在 EDS，51.7%报告嗜睡是寻求初始 OSA 治疗的促成因素。报告患有哮喘、失眠症状、每周至少 5 天每晚使用正压通气（PAP）治疗时间＜6 小时或每晚睡眠时间＜6 小时的个体中 EDS 更为常见。在调整人口统计学和合并症后，EDS 患者报告心理健康和身体健康状况较差、疾病特异性功能状态较低、活动和工作障碍更多、驾驶障碍更多（P 值＜0.05）。在 PAP 依从性较高的亚组（n=265）中，26.0%报告存在 EDS，并且在 EDS 与结局之间观察到类似的关联。
这些“真实世界”的数据表明，寻求在线 OSA 支持的患者存在较高的 EDS 患病率，这与较差的生活质量和较差的功能状态有关。在报告 PAP 治疗依从性高的受访者中，这些关联仍然存在，这可能促使这些患者因嗜睡相关症状而寻求在线支持。
