Andalusian School of Public Health (EASP). Campus Universitario de Cartuja. Granada. Spain..
An Sist Sanit Navar. 2021 Aug 20;44(2):261-273. doi: 10.23938/ASSN.0965.
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs worldwide. This makes it necessary to carry out a comprehensive synthesis of the available evidence on the safe and adequate prescription of NSAIDs in patients with cardiovascular disease, chronic kidney disease, hypertension, heart failure or liver cirrhosis and in general population. For this, a review of systematic reviews was carried out. Data extraction and analysis were performed independently by two reviewers and a narrative synthesis of the results was carried out. The use of NSAIDs is associated with a significantly higher probability of hepatotoxicity and kidney damage, as well as increased risk of exacerbation of heart failure. Taking into account the increased cardiovascular, liver and kidney risk, the prescription of NSAIDs should be carried out with caution, considering the treatment duration and the patient's situation. For this reason, patients should be informed about their possible health consequences as well as ensuring adequate monitoring of them.
非甾体抗炎药（NSAIDs）是全球应用最广泛的药物之一。这使得有必要对心血管疾病、慢性肾脏病、高血压、心力衰竭或肝硬化患者以及一般人群中 NSAIDs 安全和适当处方的现有证据进行全面综合。为此，进行了系统评价的综述。数据提取和分析由两名评审员独立进行，并对结果进行了叙述性综合。使用 NSAIDs 与肝毒性和肾损伤的可能性显著增加以及心力衰竭恶化的风险增加有关。考虑到心血管、肝脏和肾脏风险增加，应谨慎开具 NSAIDs 的处方，同时考虑治疗持续时间和患者情况。因此，应告知患者他们可能面临的健康后果，并确保对他们进行适当的监测。
