Jerlicz M, Kostowski W, Bidzinski A, Hauptmann M
Pharmacol Biochem Behav. 1978 Dec;9(6):721-4. doi: 10.1016/0091-3057(78)90346-5.
Bilateral lesions of the ventral noradrenergic bundle (VB) decreased concentration of noradrenaline within the mesendiencephalon but not in the cortex. Lesioned rats showed increased activity measured in the open field test. Cataloptogenic effects of chlorpromazine and haloperidol were almost completely abolished in VB-lesioned animals. The stereotypy induced by both--amphetamine and apomorphine was, however, unchanged. It is supposed that lesions of the VB lead to increased activity in dopaminergic neurons in the brain.
腹侧去甲肾上腺素能束（VB）的双侧损伤降低了中脑间脑内去甲肾上腺素的浓度，但皮质中的浓度未降低。在旷场试验中，损伤大鼠的活动增加。在VB损伤的动物中，氯丙嗪和氟哌啶醇的催僵作用几乎完全消失。然而，苯丙胺和阿扑吗啡诱导的刻板行为未改变。据推测，VB损伤导致大脑中多巴胺能神经元的活动增加。
