Christian Doppler Laboratory for the Biotechnology of Skin Aging, Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.
Christian Doppler Laboratory for Skin Multimodal Imaging of Aging and Senescence - SKINMAGINE, Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Austria.
Mech Ageing Dev. 2021 Sep;198:111527. doi: 10.1016/j.mad.2021.111527. Epub 2021 Jun 24.
Lipid-based signalling modulates several cellular processes and intercellular communication during wound healing and tissue regeneration. Bioactive lipids include but are not limited to the diverse group of eicosanoids, phospholipids, and extracellular vesicles and mediate the attraction of immune cells, initiation of inflammatory responses, and their resolution. In aged individuals, wound healing and tissue regeneration are greatly impaired, resulting in a delayed healing process and non-healing wounds. Senescent cells accumulate with age in vivo, preferably at sites implicated in age-associated pathologies and their elimination was shown to alleviate many age-associated diseases and disorders. In contrast to these findings, the transient presence of senescent cells in the process of wound healing exerts beneficial effects and limits fibrosis. Hence, clearance of senescent cells during wound healing was repeatedly shown to delay wound closure in vivo. Recent findings established a dysregulated synthesis of eicosanoids, phospholipids and extracellular vesicles as part of the senescent phenotype. This intriguing connection between cellular senescence, lipid-based signalling, and the process of wound healing and tissue regeneration prompts us to compile the current knowledge in this review and propose future directions for investigation.
脂质信号转导调节创伤愈合和组织再生过程中的几种细胞过程和细胞间通讯。生物活性脂质包括但不限于多种类花生酸、磷脂和细胞外囊泡，并介导免疫细胞的趋化、炎症反应的启动及其解决。在老年人中，创伤愈合和组织再生受到严重损害，导致愈合过程延迟和伤口不愈合。衰老细胞在体内随年龄积累，最好在与年龄相关的病理学相关部位积累，并且已经证明消除衰老细胞可以缓解许多与年龄相关的疾病和障碍。与这些发现相反，在创伤愈合过程中短暂存在的衰老细胞会产生有益的影响并限制纤维化。因此，体内衰老细胞的清除被反复证明会延迟伤口闭合。最近的研究结果确立了类花生酸、磷脂和细胞外囊泡合成失调是衰老表型的一部分。细胞衰老、基于脂质的信号转导以及创伤愈合和组织再生过程之间的这种有趣联系促使我们在这篇综述中汇集了当前的知识，并提出了未来的研究方向。
