Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China; Department of Neurology, Liaocheng People's Hospital, Liaocheng 252000, Shandong Province, PR China.
The Neurosurgical Department, Liaocheng People's Hospital, Liaocheng 252000, Shandong Province, PR China.
Int Immunopharmacol. 2021 Sep;98:107880. doi: 10.1016/j.intimp.2021.107880. Epub 2021 Jun 23.
Recent evidence has shown that natural killer (NK) cells have an immunoregulatory function in the pathogenesis of myasthenia gravis (MG). In this study, the phenotype and function of NK cell subsets in peripheral blood of new-onset MG (N-MG) and stable MG (S-MG) patients were explored. Circulating CD56 and CD56 NK cells were increased and decreased, respectively, in patients with N-MG and S-MG compared with healthy control (HC). Moreover, all circulating NK cell subsets from N-MG patients showed significantly lower expression of activating receptor NKG2D and production of Interferon (IFN) -γ than that from HC. The killing effects of NK cells on CD4 T cells and Tfh cells were impaired in MG patients, whereas, they promoted the differentiation and activation of Tfh cells. These data indicated that the immune-regulation of NK cells on CD4 T cells and Tfh cells in MG patients was abnormal, which may contribute to the immune-pathological mechanism of MG.
最近的证据表明，自然杀伤 (NK) 细胞在重症肌无力 (MG) 的发病机制中具有免疫调节功能。在这项研究中，我们探讨了初发 MG (N-MG) 和稳定 MG (S-MG) 患者外周血中 NK 细胞亚群的表型和功能。与健康对照 (HC) 相比，N-MG 和 S-MG 患者的循环 CD56 和 CD56 NK 细胞分别增加和减少。此外，N-MG 患者的所有循环 NK 细胞亚群表达的激活受体 NKG2D 和产生的干扰素 (IFN)-γ均明显低于 HC。MG 患者的 NK 细胞对 CD4 T 细胞和 Tfh 细胞的杀伤作用受损，而促进了 Tfh 细胞的分化和激活。这些数据表明，MG 患者 NK 细胞对 CD4 T 细胞和 Tfh 细胞的免疫调节异常，可能有助于 MG 的免疫病理机制。
