Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara, Turkey.
Department of Medical Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey.
Turk J Med Sci. 2021 Oct 21;51(5):2524-2533. doi: 10.3906/sag-2101-83.
BACKGROUND/AIM: The aim of this study was to investigate the effect of vitamin D on the disease prognosis and biochemical parameters in patients with mild obstructive sleep apnea syndrome (OSAS).
Nineteen adult male individuals (18–65 years) who were diagnosed with mild OSAS after polysomnography and had low vitamin D levels were included in the study. Each week, patients took 50.000 IU Vitamin D3 supplementation for 8 weeks. Polysomnography, biochemical parameters FBG (fasting blood glucose), lipid profile (TG, TC, LDL-C, HDL-C, VLDL-C), calcium, phosphorus, parathormone, calcitonin, serum 25(OH)D, insulin, CRP, TNF-α, IL-6, and IL-10 of patients were evaluated at the beginning of study and at the end of the study. All assessments, including polysomnography, were repeated after 8 weeks.
Serum vitamin D levels were initially 19.5 ± 5.01 ng/mL and increased to 41.8 ± 10.51 ng/mL (p < 0.001) at the end of the study. FBG, TC and HOMA-IR of the patients were significantly decreased (p < 0.05). CRP, TNF-α, IL-6, and IL-10 levels were also correlated with serum vitamin D levels (p < 0.05). There was a significant decrease in number of obstructive apneas, apneas a nd hypopneas, apnea index, hypopnea index, and apnea hypopnea index of the patients (p < 0.05).
As a result, it is thought that vitamin D supplementation may have a positive effect on the disease prognosis of mild OSAS.
背景/目的：本研究旨在探讨维生素 D 对轻度阻塞性睡眠呼吸暂停综合征（OSAS）患者疾病预后和生化参数的影响。
19 名成年男性（18-65 岁）经多导睡眠图诊断为轻度 OSAS 且维生素 D 水平较低的患者纳入本研究。每周，患者接受 50,000IU 维生素 D3 补充剂治疗 8 周。在研究开始和结束时评估患者的多导睡眠图、生化参数 FBG（空腹血糖）、血脂谱（TG、TC、LDL-C、HDL-C、VLDL-C）、钙、磷、甲状旁腺激素、降钙素、血清 25(OH)D、胰岛素、CRP、TNF-α、IL-6 和 IL-10。所有评估，包括多导睡眠图，在 8 周后重复。
患者血清维生素 D 水平最初为 19.5±5.01ng/mL，研究结束时增加至 41.8±10.51ng/mL（p<0.001）。患者的 FBG、TC 和 HOMA-IR 显著降低（p<0.05）。CRP、TNF-α、IL-6 和 IL-10 水平也与血清维生素 D 水平相关（p<0.05）。患者的阻塞性呼吸暂停次数、呼吸暂停和低通气次数、呼吸暂停指数、低通气指数和呼吸暂停低通气指数均显著减少（p<0.05）。
因此，认为维生素 D 补充可能对轻度 OSAS 的疾病预后有积极影响。
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