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2002-2015 年所有瑞典雇员的职业与 2 型糖尿病死亡率和心血管疾病负担

Mortality rates and cardiovascular disease burden in type 2 diabetes by occupation, results from all Swedish employees in 2002-2015.

机构信息

Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.

Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.

出版信息

Cardiovasc Diabetol. 2021 Jun 26;20(1):129. doi: 10.1186/s12933-021-01320-8.

Abstract

OBJECTIVE

To identify occupations where employees with type 2 diabetes have a high risk of cardiovascular disease (CVD) and mortality, and their prevalence of CVD risk factors. This study can contribute in the creation of targeted interventions at the workplace.

RESEARCH DESIGN AND METHODS

This nationwide registry-based study included all employees with type 2 diabetes born in Sweden in 1937-1979 (n = 180,620) and followed up in 2002-2015. We calculated age-standardized incidence (per 100,000 person-years) of all-cause and CVD mortality, ischemic heart disease (IHD) and stroke across the 30 most common occupations. Information on prognostic factors was retrieved from the National Diabetes Register.

RESULTS

In males with type 2 diabetes, mortality rates were highest in manufacturing workers (1782) and machine operators (1329), and lowest in specialist managers (633). The risk of death at age 61-70 years was 21.8% in manufacturing workers and 8.5% in managers. In females with type 2 diabetes, mortality rates were highest in manufacturing workers (1150) and cleaners (876), and lowest in writers and artists (458); the risk of death at age 61-70 years was 12.4% in manufacturing workers and 4.3% in writers and artists. The same occupations also had relatively high incidences of CVD mortality, IHD and stroke. Occupational groups with poor prognosis had high prevalence of CVD risk factors including poor glycemic control, smoking and obesity.

CONCLUSIONS

Manufacturing workers, machine operators and cleaners with type 2 diabetes have two to three times higher mortality rates than managers, writers and artists with type 2 diabetes. Major health gains would be made if targeted workplace interventions could reduce CVD risk factors in these occupations.

摘要

目的

确定患有 2 型糖尿病的员工心血管疾病(CVD)和死亡率风险较高的职业,以及这些职业 CVD 风险因素的流行情况。本研究有助于在工作场所制定有针对性的干预措施。

研究设计和方法

本研究是一项基于全国范围登记的研究,共纳入了 1937-1979 年在瑞典出生的所有患有 2 型糖尿病的员工(n=180620),并随访至 2002-2015 年。我们计算了所有原因和 CVD 死亡率、缺血性心脏病(IHD)和中风的年龄标准化发病率(每 10 万人年),共涵盖了 30 种最常见的职业。预后因素的信息是从国家糖尿病登记处检索到的。

结果

在患有 2 型糖尿病的男性中,制造业工人(1782 人)和机器操作员(1329 人)的死亡率最高,而专业管理人员(633 人)的死亡率最低。在 61-70 岁年龄段,制造业工人的死亡风险为 21.8%,管理人员的死亡风险为 8.5%。在患有 2 型糖尿病的女性中,制造业工人(1150 人)和清洁工(876 人)的死亡率最高,而作家和艺术家(458 人)的死亡率最低;在 61-70 岁年龄段,制造业工人的死亡风险为 12.4%,而作家和艺术家的死亡风险为 4.3%。同样的职业也有相对较高的 CVD 死亡率、IHD 和中风发生率。预后较差的职业群体,其 CVD 风险因素的患病率较高,包括血糖控制不佳、吸烟和肥胖。

结论

患有 2 型糖尿病的制造业工人、机器操作员和清洁工的死亡率比患有 2 型糖尿病的管理人员、作家和艺术家高两到三倍。如果能够在这些职业中实施有针对性的工作场所干预措施,减少 CVD 风险因素,将会带来重大的健康收益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/299d/8235252/aad171ea2628/12933_2021_1320_Fig1_HTML.jpg

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