Watson R J, Eyden B P, Howell A, Sellwood R A
Department of Surgery, University Hospital of South Manchester, Withington.
J Anat. 1988 Feb;156:1-10.
The ultrastructure of the basal lamina of histologically normal human breast tissue was determined in 19 women undergoing operations for removal of a fibroadenoma or reduction mammoplasty. The day of the menstrual cycle was determined by hormone assay and direct questioning. Previously documented ultrastructural appearances were confirmed: in addition, three morphological variants were found. In all tissue examined, there was reduplication of basal lamina in some areas, which has been described previously as a pathological feature. Also, there was complex branching of the basal lamina into the periductular connective tissue. Some projections contained cytoplasmic processes and, in almost all, hemidesmosomes were seen. The third variant consisted of loops of basal lamina thrown up in folds into the collagenous stromal cuff. Reduplication of basal lamina was detected in breast tissue removed at all stages of the menstrual cycle, looping was not and could not be related to any particular phase of the menstrual cycle. However, complex branching was seen predominantly in the periovulatory and early luteal phase. We conclude that these appearances are normal variants of basal lamina. The appearance of branching basal lamina in the luteal phase suggests that this may be produced in response to endocrine stimulation.
对19名因切除纤维腺瘤或进行乳房缩小整形手术而接受手术的女性的组织学正常的人乳腺组织基底膜超微结构进行了测定。月经周期的日期通过激素测定和直接询问来确定。先前记录的超微结构表现得到了证实；此外，还发现了三种形态学变异。在所有检查的组织中，某些区域存在基底膜重复，这在以前被描述为一种病理特征。此外，基底膜向导管周围结缔组织呈复杂分支。一些突起包含细胞质突起，并且在几乎所有突起中都可见半桥粒。第三种变异由基底膜的环圈组成，这些环圈向上折叠进入胶原性基质袖套。在月经周期各阶段切除的乳腺组织中均检测到基底膜重复，而环圈现象未检测到，且与月经周期的任何特定阶段无关。然而，复杂分支主要出现在排卵期和黄体早期。我们得出结论，这些表现是基底膜的正常变异。黄体期基底膜分支的出现表明这可能是对内分泌刺激的反应。
