小鼠和家兔软脑膜巨噬细胞发育的超微结构研究

Department of Anatomy, University of Dundee, Scotland.

J Anat. 1988 Feb;156:207-15.

Macrophages can be identified in the leptomeninges of the mouse and rabbit spinal cord at E11 and E12 respectively. Initially macrophages contained few cytoplasmic organelles and had long, narrow convoluted processes. By E14 in the mouse and E16 in the rabbit the macrophages were well differentiated with short processes; the cytoplasm contained vacuoles of varying sizes, dense bodies, mitochondria, free ribosomes and rough endoplasmic reticulum. In the young postnatal mouse leptomeningeal macrophages contained numerous small cytoplasmic vacuoles. Leptomeningeal fibroblasts containing varying amounts of cell debris were also found in both pial and arachnoid layers in both species examined but there was no evidence of transformation of leptomeningeal fibroblasts into macrophages.

在小鼠和兔子的脊髓软脑膜中，分别于胚胎第11天和第12天可识别出巨噬细胞。最初，巨噬细胞含有少量细胞质细胞器，具有长而窄的卷曲突起。到小鼠胚胎第14天和兔子胚胎第16天，巨噬细胞已充分分化，突起变短；细胞质中含有大小不一的液泡、致密体、线粒体、游离核糖体和粗面内质网。在出生后的幼鼠中，软脑膜巨噬细胞含有大量小的细胞质液泡。在所检查的两个物种的软膜和蛛网膜层中，均发现含有不同数量细胞碎片的软脑膜成纤维细胞，但没有证据表明软脑膜成纤维细胞会转化为巨噬细胞。