Research Laboratory in Muscular System and Physical Exercise, University of Northern Paraná, Londrina, Brazil.
Research Group in Physiology and Physical Activity, University of Northern Paraná, Londrina, Brazil.
J Diet Suppl. 2022;19(6):772-790. doi: 10.1080/19390211.2021.1939473. Epub 2021 Jun 26.
Although the ergogenic mechanisms of supplementation with citrulline malate are well known, unclear findings regarding variables of muscle strength have been recorded. Such misleading findings in the literature illustrate the need for well-conducted meta-analysis research to elucidate the possible ergogenic impact, which could have major practical consequences for athletes and recreational practitioners seeking to optimize gains in muscle strength. The objective of this systematic review was to summarize the existing literature that evaluated the effects of citrulline malate supplementation on muscle strength outcomes from resistance exercise in resistance-trained individuals. A systematic electronic search in Medline and Scientific Electronic Library Online (SciELO) was completed in August 2020 identifying randomized controlled trials investigating the effect of citrulline malate supplementation on muscle strength in resistance-trained adults. A subsequent meta-analysis was performed. The meta-analysis involved four studies and 138 assessments (69 in citrulline-malate and 69 in placebo groups). We did not observe an overall effect favoring citrulline-malate supplementation (SMD = 0.13 [-0.21; 0.46]). Considering the lower (SMD = 0.06 [-0.47; 0.60]) and upper (SMD = 0.17 [-0.26; 0.60]) limbs, a non-significant overall effect was identified. The mean effects were similar for "limbs" (upper vs lower) [ = 0.763]. Accordingly, our findings suggest that citrulline malate supplementation does not improve muscle strength in healthy and resistance-trained individuals (PROSPERO registration number: CRD42020159338).
虽然瓜氨酸苹果酸的增效作用机制已被广泛研究，但有关肌肉力量变量的研究结果仍不明确。文献中存在这些误导性的结果，表明需要进行精心设计的荟萃分析研究，以阐明其可能的增效作用，这对于寻求优化肌肉力量增益的运动员和业余健身爱好者可能具有重要的实际意义。本系统评价的目的是总结现有的文献，评估瓜氨酸苹果酸补充剂对经过抗阻训练的个体进行抗阻运动后肌肉力量的影响。2020 年 8 月，我们在 Medline 和 Scientific Electronic Library Online（SciELO）上进行了系统的电子检索，以确定调查瓜氨酸苹果酸补充剂对成年抗阻训练者肌肉力量影响的随机对照试验。随后进行了荟萃分析。荟萃分析涉及四项研究和 138 项评估（69 项在瓜氨酸苹果酸盐组，69 项在安慰剂组）。我们没有观察到瓜氨酸苹果酸盐补充剂有总体的优势（SMD = 0.13 [-0.21; 0.46]）。考虑到上下肢（SMD = 0.06 [-0.47; 0.60]）的结果，我们发现总体效应无统计学意义。“四肢”（上肢与下肢）的平均效应相似[ = 0.763]。因此，我们的研究结果表明，瓜氨酸苹果酸补充剂并不能提高健康和抗阻训练个体的肌肉力量（PROSPERO 注册号：CRD42020159338）。
