Shea C, Morse E D
Ann Clin Lab Sci. 1978 Jan-Feb;8(1):30-3.
A direct inhibitory effect of hydrocortisone on granulocyte chemotaxis has been demonstrated with an increasing inhibition between concentrations of 5 microgram to 12.5 microgram per ml. Washing the granulocytes after incubation with hydrocortisone did not reverse the inhibitory effect on chemotaxis indicating a direct cellular effect. Bacteriocidal capacity of the hydrocortisone treated cells was not reduced. These studies indicate corticosteroids, alter motility of granulocytes irreversibly possibly by incorporation into the cell membrane.
氢化可的松对粒细胞趋化性有直接抑制作用，已证实在每毫升5微克至12.5微克的浓度之间抑制作用增强。用氢化可的松孵育粒细胞后洗涤，并未逆转对趋化性的抑制作用，这表明存在直接的细胞效应。氢化可的松处理过的细胞的杀菌能力并未降低。这些研究表明，皮质类固醇可能通过掺入细胞膜不可逆地改变粒细胞的运动性。
