Gnarpe H, Belsheim J, Persson S
Scand J Infect Dis Suppl. 1981;26:68-71.
Spontaneous and directed neutrophil granulocyte migration are known to be depressed in patients with various clinical disorders, for example those in an active phase of Crohn's disease. The effects of tinidazole, ornidazole, metronidazole and levamisole on the migration of neutrophil granulocytes in patients with Crohn's disease were investigated. It was shown that nitroimidazole derivatives improved the migration of granulocytes in most of the patients with Crohn's disease but that they had no effect on normal cells. It was also shown that washing of the neutrophil granulocytes with Krebs Ringers phosphate medium resulted in normalization of cell motility. It is possible that the nitroimidazole derivatives improve leukocyte migration by causing a release of surface-attached complexes from the granulocytes.
已知在患有各种临床疾病的患者中，例如处于克罗恩病活动期的患者，自发和定向的中性粒细胞迁移会受到抑制。研究了替硝唑、奥硝唑、甲硝唑和左旋咪唑对克罗恩病患者中性粒细胞迁移的影响。结果表明，硝基咪唑衍生物可改善大多数克罗恩病患者的粒细胞迁移，但对正常细胞无影响。还表明，用磷酸 Krebs-Ringer 培养基洗涤中性粒细胞可使细胞运动恢复正常。硝基咪唑衍生物可能通过促使粒细胞表面附着的复合物释放来改善白细胞迁移。
