Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
Biomedical Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom.
Front Immunol. 2021 Jun 10;12:694086. doi: 10.3389/fimmu.2021.694086. eCollection 2021.
Cells of the skin and circulation are in constant two-way communication. Following exposure of humans to sunlight or to phototherapy, there are alterations in the number, phenotype and function of circulating blood cells. In this review, only data obtained from human studies are considered, with changes induced by UV radiation (UVR) exposure described for phagocytic leukocytes and peripheral blood mononuclear cells plus their component T and B cells, natural killer cells and dendritic cells. These immune modulations illustrate the potential of UVR to have therapeutic effects beyond the skin, and that sunlight exposure is an important environmental influence on human health.
皮肤和循环系统的细胞之间存在持续的双向通讯。在人体暴露于阳光或光疗后,循环血液细胞的数量、表型和功能会发生改变。在本综述中,仅考虑了来自人体研究的数据,描述了紫外线辐射 (UVR) 暴露对吞噬白细胞和外周血单个核细胞及其组成的 T 和 B 细胞、自然杀伤细胞和树突状细胞所诱导的变化。这些免疫调节表明 UVR 具有超越皮肤的治疗效果的潜力,并且阳光暴露是对人类健康的重要环境影响。