Yang Fengguang, Wang Jizu, Chen Zhixin, Yang Yuping, Zhang Wenhui, Guo Shifang, Yang Qingshan
Department of Orthopedics, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.
Exp Ther Med. 2021 Aug;22(2):860. doi: 10.3892/etm.2021.10292. Epub 2021 Jun 10.
The incidence of lower back pain caused by intervertebral disc degeneration (IDD) is gradually increasing. IDD not only affects the quality of life of the patients, but also poses a major socioeconomic burden. There is currently no optimal method for delaying or reversing IDD, mainly due to its unknown pathogenesis. MicroRNAs (miRNAs/miRs) participate in the development of a number of diseases, including IDD. Abnormal expression of miRNAs in the intervertebral disc is implicated in various pathological processes underlying the development of IDD, including nucleus pulposus (NP) cell (NPC) proliferation, NPC apoptosis, extracellular matrix remodeling, inflammation and cartilaginous endplate changes, among others. The focus of the present review was the advances in research on the involvement of miRNAs in the mechanism underlying IDD. Further research is expected to identify markers for early diagnosis of IDD and new targets for delaying or reversing IDD.
椎间盘退变（IDD）所致下背痛的发病率正逐渐上升。IDD不仅影响患者的生活质量，还带来重大的社会经济负担。目前尚无延迟或逆转IDD的最佳方法，主要原因是其发病机制不明。微小RNA（miRNA/miR）参与包括IDD在内的多种疾病的发展过程。椎间盘内miRNA的异常表达与IDD发生发展的各种病理过程有关，包括髓核（NP）细胞（NPC）增殖、NPC凋亡、细胞外基质重塑、炎症及软骨终板改变等。本综述的重点是miRNA参与IDD发病机制的研究进展。期望进一步的研究能够确定IDD的早期诊断标志物以及延迟或逆转IDD的新靶点。
