Ueda Keisuke, Kim Soyoung, Greene Deanna J, Black Kevin J
Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Curr Dev Disord Rep. 2021 Jun;8(2):112-120. doi: 10.1007/s40474-021-00230-4. Epub 2021 Apr 4.
Tic disorders are common in the pediatric population and are differentiated from other movement disorders by tic suppressibility. Understanding the mechanism of tic suppression may provide new insights to the pathophysiology of tic disorders. This article highlights clinical phenomenology and neuronal correlates of tic suppressibility.
Recent studies suggest that tic suppressibility exists in children shortly after onset of their tics. Moreover, those who are better able to suppress their tics have better tic outcomes. Interoceptive awareness and automatic action inhibition may be involved in tic suppression.
We illustrate a possible underlying mechanism of tic suppressibility and its clinical correlations and implications. New concepts such as interoceptive awareness and action inhibition may help explain tic disorders. Further study will be useful to fill remaining knowledge gaps.
抽动障碍在儿童群体中很常见，且通过抽动可抑制性与其他运动障碍相区分。了解抽动抑制的机制可能为抽动障碍的病理生理学提供新的见解。本文重点介绍抽动可抑制性的临床现象学和神经关联。
近期研究表明，抽动障碍患儿在抽动发作后不久就存在抽动可抑制性。此外，那些更能抑制抽动的患儿抽动结局更好。内感受性觉知和自动动作抑制可能参与了抽动抑制。
我们阐述了抽动可抑制性的一种潜在机制及其临床关联和意义。内感受性觉知和动作抑制等新概念可能有助于解释抽动障碍。进一步的研究将有助于填补尚存的知识空白。
