Comparison of the Prevalence of Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMMs) among Isolates in a Burn Unit with Non-Burning Units.

BACKGROUND

() is one of the most important pathogens in burn infections colonized in the nose and increase the risk of infections.

METHODS

Overall, 85 isolates were isolated from clinical and nasal hospitalized patients and health care workers (HCWs) in a burn unit and non-burn units in Isfahan from June 2016 and September 2016. Genes encoding penicillin-binding protein 2a A) and adhesive surface proteins, including fibronectin-binding proteins (,), fibrinogen binding protein (), laminin-binding protein(), collagen binding protein (), elastin binding protein intracellular adhesion operon (A and D) were detected using PCR method.

RESULTS

The rate of methicillin-resistant (MRSA) among burn and non-burn isolates were 62% (18/29) and 25% (14/56), respectively. The most prevalent MSCRAMMs genes in burn units were (86%) and (66%). The most common gene pattern in burn center was A++ The frequency of D, and S was higher in clinical samples than nasal samples. No relation was found between the MSCRAMMs genes in the burn unit and non-burn units.

CONCLUSION

The high prevalence of MRSA in burn center can be a new challenge for clinicians. The higher frequency of D, and S in clinical isolates than nasal isolates may reflect the important role of these genes in colonization and pathogenesis of .