Heydarian Peyman, Ashrafi Keyhan, Rahimi Esboei Bahman, Mohe-Bali Mehdi, Kia Eshrat Beigom, Aryaeipour Mojgan, Bozorgomid Arezoo, Chegeni Sharafi Ali, Mokhayeri Hamid, Rokni Mohammad Bagher
Department of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Medical Parasitology and Mycology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Iran J Public Health. 2021 Jan;50(1):195-200. doi: 10.18502/ijph.v50i1.5087.
Fascioliasis is a zoonotic disease caused by spp. We report five serologically and molecularly confirmed cases in an emerging region in Iran. A retrospective, case series study, performed in Lorestan Province, west of Iran between January 2015 and June 2016. From 1256 patients examined, 16 patients had positive serum ELISA. Five cases were approved as infected with fasciolosis using stool exam and PCR. Age ranged from 24 to 80 yr with mean age of 45 years. All of patients were adults and four of them had abdominal and back pain. Other symptoms included fever and chills, coughing and sore throat, weight loss, cutaneous manifestations. All patients lived in the rural environment, and four reported the ingestion of raw aquatic plants such as watercress. In fecal examination for fluke eggs, four samples were positive for eggs. Conventional PCR analysis showed that five human stools were positive for . All of 5 patients were treated with the usual dose of triclabendazole. A history of recent consumption of raw aquatic plants (in 4 out of 5 patients) is an important finding, but in one patient the source of infection remained unclear. Lorestan should be considered as an emerging region for this disease and further research in this province should be carried out.
肝片吸虫病是一种由肝片吸虫属物种引起的人畜共患病。我们报告了伊朗一个新兴地区的5例经血清学和分子学确诊的病例。这是一项回顾性病例系列研究，于2015年1月至2016年6月在伊朗西部的洛雷斯坦省进行。在1256名接受检查的患者中，16例患者血清ELISA呈阳性。通过粪便检查和PCR，5例被确诊感染肝片吸虫病。年龄范围为24至80岁，平均年龄45岁。所有患者均为成年人，其中4人有腹痛和背痛。其他症状包括发热、寒战、咳嗽、喉咙痛、体重减轻、皮肤表现。所有患者都生活在农村环境中，4人报告食用过诸如水田芥等生水植物。在粪便检查吸虫卵时，4份样本的吸虫卵呈阳性。常规PCR分析显示，5份人类粪便样本的肝片吸虫呈阳性。所有5例患者均接受了常规剂量的三氯苯达唑治疗。近期食用生水植物的病史（5例中有4例）是一个重要发现，但有1例患者的感染源仍不清楚。洛雷斯坦应被视为该病的一个新兴地区，应对该省开展进一步研究。
