Wang Benyong, Gao Chan, Chen Qi, Wang Ming, Fei Xiao, Zhao Ning
Department of Nephrology, Affiliated Hangzhou First People's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Iran J Public Health. 2021 Mar;50(3):502-509. doi: 10.18502/ijph.v50i3.5591.
To detect the serum procalcitonin (PCT) levels of peritoneal dialysis (PD) patients.
We analyzed the relationship between the PCT Level and dialysis adequacy. We studied 120 peritoneal dialysis patients without signs of infection in Affiliated Hangzhou First People's Hospital and 120 controls from Jan 2014 to Apr 2016. PCT and high sensitivity C-reactive protein (hs-CRP) were detected. 120 PD patients were divided into two groups according to the dialysis adequacy. A correlation analysis was processed between the PCT level and the total solute clearance (Kt/V). The value of PCT for identifying the dialysis adequacy in PD patients was assessed by ROC curve analysis.
PCT level in serum of PD group (0.29±0.24 ng/ml) was higher than that of the control group (0.02±0.01 ng/ml) (<0.01). Compared with the inadequate dialysis group (0.5±0.37 ng/ml), the PCT Level of the adequate dialysis group (0.23±0.15 ng/ml) was lower (<0.01). There were negative correlations between PCT and Kt/v(r=-0.451), Prealbumin (PA) (r=-0.258), Glomerular Filtration Rate (eGFR; r=-0.280), while there was positive correlation between PCT and Hypersensitive c-reactive protein (r=0.458) (<0.01). At a serum PCT cut-off value of 0.283 ng/ml, the sensitivity and specificity for identifying the dialysis adequacy in PD patients were 0.913 and 0.805 respectively. The serum levels of PCT in peritoneal dialysis patients were significantly higher than the levels in healthy controls.
The serum level of PCT can be used as an indirect maker to evaluate the adequacy of dialysis.
检测腹膜透析（PD）患者的血清降钙素原（PCT）水平。
分析PCT水平与透析充分性之间的关系。2014年1月至2016年4月，我们研究了杭州市第一人民医院120例无感染迹象的腹膜透析患者以及120例对照者。检测PCT和高敏C反应蛋白（hs-CRP）。120例PD患者根据透析充分性分为两组。对PCT水平与总溶质清除率（Kt/V）进行相关性分析。通过ROC曲线分析评估PCT对识别PD患者透析充分性的价值。
PD组血清PCT水平（0.29±0.24 ng/ml）高于对照组（0.02±0.01 ng/ml）（<0.01）。与透析不充分组（0.5±0.37 ng/ml）相比，透析充分组的PCT水平（0.23±0.15 ng/ml）较低（<0.01）。PCT与Kt/v（r=-0.451）、前白蛋白（PA）（r=-0.258）、肾小球滤过率（eGFR；r=-0.280）呈负相关，而PCT与超敏C反应蛋白呈正相关（r=0.458）（<0.01）。血清PCT临界值为0.283 ng/ml时，识别PD患者透析充分性的灵敏度和特异度分别为0.913和0.805。腹膜透析患者的血清PCT水平显著高于健康对照组。
血清PCT水平可作为评估透析充分性的间接指标。
