Abu-Dahab Rana, Mahmoud Nouf N, Abdallah Maha, Hamadneh Lama, Hikmat Suhair, Zaza Rand, Abuarqoub Duaa, Khalil Enam A
School of Pharmacy, The University of Jordan, Amman 11942, Jordan.
Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
ACS Omega. 2021 Jun 11;6(24):15903-15910. doi: 10.1021/acsomega.1c01386. eCollection 2021 Jun 22.
Herein, the antiproliferative effect of surface-decorated gold nanorods (GNRs) was investigated against three different breast cancer cell lines. The results indicate that the cell lines exhibited different biological responses and death modalities toward the treatment. The cell lines exhibited similar cellular uptake of the nanoparticles; however, MDA-MB-231 demonstrated the highest cytotoxicity compared to other cell lines upon treatment with GNRs. The expression of the gene, which is involved in cell adhesion and metastasis, was dramatically increased in treated MDA-MB-231 cells compared to other cell lines. Early apoptosis and late apoptosis are the dominant cellular death modalities of MDA-MB-231 cells upon treatment with GNRs.
在此，研究了表面修饰的金纳米棒（GNRs）对三种不同乳腺癌细胞系的抗增殖作用。结果表明，这些细胞系对该处理表现出不同的生物学反应和死亡方式。这些细胞系对纳米颗粒表现出相似的细胞摄取；然而，在用GNRs处理后，与其他细胞系相比，MDA-MB-231表现出最高的细胞毒性。与其他细胞系相比，参与细胞黏附和转移的基因在经处理的MDA-MB-231细胞中的表达显著增加。早期凋亡和晚期凋亡是MDA-MB-231细胞在用GNRs处理后的主要细胞死亡方式。
Zotero 插件