Department of General Biophysics, Faculty of Biology and Environmental Protection , University of Lodz , 141/143 Pomorska St. , 90-236 Lodz , Poland.
Leibniz Institute of Polymer Research Dresden , 6 Hohe St. , 01069 Dresden , Germany.
Mol Pharm. 2019 Jan 7;16(1):1-23. doi: 10.1021/acs.molpharmaceut.8b00810. Epub 2018 Nov 30.
Colloidal gold has been studied for its potential application in medicine for centuries. However, synthesis and evaluation of various gold nanoparticles have only recently been met with a wide interest of scientists. Current studies confirm numerous advantages of nanogold over different nanomaterials, primarily due to highly optimized protocols for the production of gold nanoparticles of countless sizes and shapes, featured with unique properties. The possibility to modify the surface of nanogold particles with different targeting and functional compounds significantly broadens the range of their potential biomedical applications, with particular emphasis on cancer treatment. Functionalized gold nanoparticles exhibit good biocompatibility and controllable biodistribution patterns, which make them particularly fine candidates for the basis of innovative therapies. Considering the high amount of scientific data on nanogold, this review summarizes recent advances in the field of medical application of gold nanoparticles for the therapy of cancer.
胶体金在医学领域的潜在应用已被研究了几个世纪。然而，各种金纳米粒子的合成和评估最近才引起了科学家们的广泛关注。目前的研究证实，纳米金在许多方面优于其他纳米材料，主要是因为其具有高度优化的生产方案，可以生产出无数大小和形状的金纳米粒子，并具有独特的性质。通过不同的靶向和功能化合物对纳米金粒子表面进行修饰，大大拓宽了其潜在的生物医学应用范围，尤其是在癌症治疗方面。功能化的金纳米粒子具有良好的生物相容性和可控制的生物分布模式，这使得它们成为创新疗法的理想候选材料。考虑到大量关于纳米金的科学数据，本文综述了金纳米粒子在癌症治疗中的医学应用领域的最新进展。
