Hainan Provincial Fine Chemical Engineering Research Center, School of Chemical Engineering and Technology, Hainan University, Haikou, P.R. China.
Nat Prod Res. 2022 Oct;36(19):5069-5073. doi: 10.1080/14786419.2021.1916017. Epub 2021 Jun 28.
Chemical investigation of endophytic fungus HQD24, isolated from the flower of led to the isolation of eight alkaloids, including pyripyropene A (), 1,11-dideacetyl-pyripyropene A (), pyripyropene E (), chaetominine (), tryptoquivaline J (), fumitremorgin C (), 1-acetyl-β-carboline (), and nicotinic acid (). Their structures were unambiguously elucidated on the basis of extensive spectroscopic data and comparison with the data of literature. Compound was known as a synthetic product and isolated as a natural product for the first time. The immunosuppressive and cytotoxic activities of all isolated compounds were evaluated.
从 Led 花中分离得到的内生真菌 HQD24 的化学成分研究导致了八种生物碱的分离，包括吡咯并吡咯酮 A()、1,11-二乙酰基吡咯并吡咯酮 A()、吡咯并吡咯酮 E()、麦角胺()、色胺酮 J()、伏马菌素 C()、1-乙酰-β-咔啉()和烟酸()。根据广泛的光谱数据和与文献数据的比较，明确了它们的结构。化合物是一种已知的合成产物，也是首次作为天然产物分离得到。评价了所有分离化合物的免疫抑制和细胞毒性活性。
