Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.
Mar Drugs. 2013 Jul 23;11(7):2682-94. doi: 10.3390/md11072682.
Four new quinazolinone alkaloids, namely, aniquinazolines A-D (1-4), were isolated and identified from the culture of Aspergillus nidulans MA-143, an endophytic fungus obtained from the leaves of marine mangrove plant Rhizophora stylosa. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined on the basis of chiral HPLC analysis of the acidic hydrolysates. The structure for 1 was confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality.
从海洋红树林植物红树（Rhizophora stylosa）叶片内生真菌 Aspergillus nidulans MA-143 的培养物中分离鉴定了 4 种新的喹唑啉酮生物碱，即 aniquinazolines A-D（1-4）。通过光谱分析阐明了新化合物的结构，并基于酸性水解产物的手性 HPLC 分析确定了它们的绝对构型。1 的结构通过单晶 X 射线衍射分析得到证实。所有这些化合物都进行了抗菌和细胞毒性活性以及卤虫（Artemia salina）致死性检测。
