Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Alzheimer's Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea.
J Alzheimers Dis. 2021;82(4):1591-1599. doi: 10.3233/JAD-210119.
An association between Helicobacter pylori (H. pylori) infection and dementia was reported in previous studies; however, the evidence is inconsistent.
In the present study, the association between H. pylori infection and brain cortical thickness as a biomarker of neurodegeneration was investigated.
A cross-sectional study of 822 men who underwent a medical health check-up, including an esophagogastroduodenoscopy and 3.0 T magnetic resonance imaging, was performed. H. pylori infection status was assessed based on histology. Multiple linear regression analyses were conducted to evaluate the relationship between H. pylori infection and brain cortical thickness.
Men with H. pylori infection exhibited overall brain cortical thinning (p = 0.022), especially in the parietal (p = 0.008) and occipital lobes (p = 0.050) compared with non-infected men after adjusting for age, educational level, alcohol intake, smoking status, and intracranial volume. 3-dimentional topographical analysis showed that H. pylori infected men had cortical thinning in the bilateral lateral temporal, lateral frontal, and right occipital areas compared with non-infected men with the same adjustments (false discovery rate corrected, Q < 0.050). The association remained significant after further adjusting for inflammatory marker (C-reactive protein) and metabolic factors (obesity, dyslipidemia, fasting glucose, and blood pressure).
Our results indicate H. pylori infection is associated with neurodegenerative changes in cognitive normal men. H. pylori infection may play a pathophysiologic role in the neurodegeneration and further studies are needed to validate this association.
先前的研究报告显示，幽门螺杆菌（H. pylori）感染与痴呆之间存在关联；然而，证据并不一致。
本研究旨在探讨 H. pylori 感染与作为神经退行性变生物标志物的大脑皮质厚度之间的关系。
对 822 名接受医学健康检查（包括食管胃十二指肠镜检查和 3.0T 磁共振成像）的男性进行了横断面研究。根据组织学评估 H. pylori 感染状况。采用多元线性回归分析评估 H. pylori 感染与大脑皮质厚度之间的关系。
与未感染的男性相比，感染 H. pylori 的男性表现出全脑皮质变薄（p=0.022），尤其是顶叶（p=0.008）和枕叶（p=0.050），调整年龄、教育水平、饮酒量、吸烟状况和颅内体积后。三维拓扑分析显示，与未感染的男性相比，感染 H. pylori 的男性双侧外侧颞叶、外侧额叶和右侧枕叶的皮质变薄（经假发现率校正，Q<0.050）。在进一步调整炎症标志物（C 反应蛋白）和代谢因素（肥胖、血脂异常、空腹血糖和血压）后，这种关联仍然显著。
我们的研究结果表明，H. pylori 感染与认知正常男性的神经退行性变化有关。H. pylori 感染可能在神经退行性变中发挥病理生理作用，需要进一步研究来验证这种关联。
