Beydoun May A, Beydoun Hind A, Hu Yi-Han, Li Zhiguang, Wolf Claudia, Meirelles Osorio, Noren Hooten Nicole, Launer Lenore J, Evans Michele K, Zonderman Alan B
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, Baltimore, MD, USA.
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, Baltimore, MD, USA; Alexander T. Augusta Military Medical Center, Fort Belvoir, VA, USA.
Brain Behav Immun. 2024 Jan;115:394-405. doi: 10.1016/j.bbi.2023.10.009. Epub 2023 Oct 17.
Infection burden (IB), although linked to neurodegeneration, including Alzheimer's Disease (AD), has not been examined against neurite orientation, dispersion, and density imaging (NODDI) measures.
Among 38,803 UK Biobank adults (Age:40-70 years), we tested associations of total IB (IB, 47.5 %) and hospital-treated IB (IB, 9.7 %) with NODDI measures (5-15 years later), including volume fraction of Gaussian isotropic diffusion (ISOVF), intra-cellular volume fraction (ICVF) and orientation dispersion (OD) indices, using multiple linear regression models.
Total and hospital-treated infection burdens (IB and IB) were associated with increased ISOVF, indicating increased free-water component. IB was positively associated with OD, indicating that at higher IB there was greater fanning of neurites. This was more evident in the lower cardiovascular health group. IB was associated with higher OD, and lower ICVF at higher AD polygenic risk. Together, these findings indicate that both total and hospital-treated infections have effects on NODDI outcomes in the direction of poor brain health. These effects were largely homogeneous across cardiovascular health and AD polygenic risk groups, with some effects shown to be stronger at poor cardiovascular health and/or higher AD risk.
Total and hospital-treated infections were associated with poorer white matter microstructure (higher ISOVF or OD or lower ICVF), with some heterogeneity across cardiovascular health and AD risk. Longitudinal studies with multiple repeats on neuroimaging markers in comparable samples are needed.
感染负担（IB）虽然与神经退行性变有关，包括阿尔茨海默病（AD），但尚未针对神经突方向、离散度和密度成像（NODDI）指标进行研究。
在38803名英国生物银行成年参与者（年龄：40 - 70岁）中，我们使用多元线性回归模型测试了总感染负担（IB，47.5%）和医院治疗的感染负担（IB，9.7%）与NODDI指标（5 - 15年后）之间的关联，这些指标包括高斯各向同性扩散体积分数（ISOVF）、细胞内体积分数（ICVF）和方向离散度（OD）指数。
总感染负担和医院治疗的感染负担（IB和IB）与ISOVF增加有关，表明自由水成分增加。IB与OD呈正相关，表明在较高的IB水平下神经突扇形化程度更高。这在心血管健康状况较差的组中更为明显。在较高的AD多基因风险下，IB与较高的OD和较低的ICVF相关。总之，这些发现表明，总感染和医院治疗的感染均对NODDI结果产生影响，导致脑健康状况变差。这些影响在心血管健康和AD多基因风险组中基本一致，在心血管健康状况较差和/或AD风险较高时，一些影响更为明显。
总感染和医院治疗的感染与较差的白质微观结构（较高的ISOVF或OD或较低的ICVF）有关，在心血管健康和AD风险方面存在一些异质性。需要在可比样本中对神经影像标志物进行多次重复的纵向研究。
