Aghaeipour Farideh, Salehiniya Hamid, Abbaszadeh Hamid
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran.
J Med Virol. 2021 Nov;93(11):6089-6099. doi: 10.1002/jmv.27161. Epub 2021 Jul 6.
The role of human papillomavirus (HPV) in the development of oral lesions is controversial. There has been no comprehensive study about HPV prevalence in Iran. This systematic review and meta-analysis were aimed at finding HPV prevalence of oral lesions and normal oral mucosa in Iran. International (PubMed, Web of Science, and Scopus) and national (Iranmedex, Irandoc, and SID) databases were searched systematically until October 2020. Studies that examined the prevalence of HPV in oral lesions by polymerase chain reaction method were included. The heterogeneity of articles was assessed with the Cochran test and I-Square statistics. The prevalence rate of HPV was calculated using a random-effect model. Of 3729 initially searched articles, 29 articles were eligible for inclusion. The overall prevalence of HPV in oral lesions was 21%. The prevalence was the highest in Rasht (50%) city. Lip lesions had the highest HPV prevalence (40%). According to the classification of lesions, the highest prevalence was of precancerous lesions (29%) and the lowest in normal mucosa (8%). Well-differentiated tumors showed a higher prevalence than poorly-differentiated ones. The highest prevalence of HPV was hairy leukoplakia (70%) and the lowest was of pyogenic granuloma (6%). Also, the prevalence was 31% in oral squamous cell carcinoma. There are differences between HPV prevalence according to the geographical area, intraoral location, type of lesion, and grading. As HPV prevalence was fairly high, further attention to vaccination and treatment for HPV in Iran, as a potential risk factor for oral precancerous and cancerous lesions is recommended.
人乳头瘤病毒（HPV）在口腔病变发展中的作用存在争议。伊朗尚未有关于HPV患病率的全面研究。本系统评价和荟萃分析旨在确定伊朗口腔病变和正常口腔黏膜中HPV的患病率。系统检索了国际数据库（PubMed、科学网和Scopus）和国内数据库（伊朗医学数据库、伊朗文献数据库和SID），检索截至2020年10月。纳入采用聚合酶链反应法检测口腔病变中HPV患病率的研究。用 Cochr an检验和I²统计量评估文章的异质性。采用随机效应模型计算HPV患病率。在最初检索的3729篇文章中，有29篇符合纳入标准。口腔病变中HPV的总体患病率为21%。在拉什特市（50%）患病率最高。唇部病变的HPV患病率最高（40%）。根据病变分类，癌前病变的患病率最高（29%），正常黏膜的患病率最低（8%）。高分化肿瘤的患病率高于低分化肿瘤。HPV患病率最高的是毛状白斑（70%），最低的是化脓性肉芽肿（6%）。口腔鳞状细胞癌中的患病率也为31%。根据地理区域、口腔内位置、病变类型和分级，HPV患病率存在差异。由于HPV患病率相当高，建议伊朗进一步关注HPV的疫苗接种和治疗，因为它是口腔癌前病变和癌性病变的潜在危险因素。
