Department of Radiation Oncology, State Hospital Mater Salutis, 37045, AUSLSS 9, Verona, Italy.
Department of Radiation Oncology, University Hospital, 44124, Ferrara, Italy.
Immunotherapy. 2021 Aug;13(12):971-976. doi: 10.2217/imt-2021-0039. Epub 2021 Jun 28.
Abscopal effect has been mentioned for a long time, but only recently a deeper knowledge about underlying mechanisms supporting the interaction between immune system and radiation therapy became available. Furthermore, the introduction of immune-checkpoint inhibitors makes appealing the idea of combining them with radiotherapy (RT) to elicit abscopal effect and ideally revert an intrinsic or acquired resistance. Herein, we present the case of a non-small-cell lung cancer patient undergoing, during second line nivolumab, palliative RT on thoracic wall lesion, achieving a complete response in the metastatic adrenal site. This case report suggests that the abscopal effect exists in clinical practice of lung cancer care likely due to a synergism between immune-checkpoint and RT, even when administered with a palliative intent.
远隔效应很早就被提及，但直到最近，人们对支持免疫系统和放射治疗相互作用的潜在机制有了更深入的了解。此外，免疫检查点抑制剂的引入使得人们希望将它们与放射治疗（RT）结合使用，以引发远隔效应，并理想地逆转内在或获得性耐药。在此，我们报告了一例非小细胞肺癌患者在二线纳武单抗治疗期间接受胸壁病变姑息性 RT 的病例，转移性肾上腺部位达到完全缓解。该病例报告表明，远隔效应可能存在于肺癌治疗的临床实践中，这是由于免疫检查点和 RT 之间的协同作用，即使是以姑息为目的进行治疗。
