Hixson L J, Morgan T R, Sampliner R E
University of Arizona Health Sciences Center, Tucson.
J Clin Gastroenterol. 1988 Apr;10(2):201-4. doi: 10.1097/00004836-198804000-00020.
Two patients with chronic abdominal pain and fasting hypergastrinemia had increases in serum gastrin of 440 and 300 pg/ml after injection of 2 U/kg Secretin-KABI. Both subsequently proved to have pentagastrin-fast achlorhydria. Intragastric instillation of 0.1 N HCl suppressed serum gastrin concentration by greater than 60%. In both, the pancreas was normal by sonography or computed tomography (CT) scan and at laparotomy in one. Both are currently asymptomatic 12 and 18 months later. We conclude that achlorhydria may be associated after injection of Secretin-KABI with a false-positive rise in fasting serum gastrin concentration of greater than 200 pg/ml and that gastric analysis for hypochlorhydria should be performed before secretin provocation testing.
两名患有慢性腹痛和空腹高胃泌素血症的患者，在注射2 U/kg的赛瑞克林（Secretin-KABI）后，血清胃泌素分别升高了440和300 pg/ml。随后两人均被证实存在五肽胃泌素激发无胃酸分泌。胃内滴注0.1 N盐酸可使血清胃泌素浓度降低超过60%。两人通过超声或计算机断层扫描（CT）检查胰腺均正常，其中一人接受了剖腹探查，胰腺也正常。12个月和18个月后，两人目前均无症状。我们得出结论，注射赛瑞克林后胃酸缺乏可能与空腹血清胃泌素浓度出现大于200 pg/ml的假阳性升高有关，并且在进行促胰液素激发试验之前应进行胃酸缺乏的胃液分析。
