Feldman M, Schiller L R, Walsh J H, Fordtran J S, Richardson C T
Gastroenterology. 1987 Jul;93(1):59-62. doi: 10.1016/0016-5085(87)90314-3.
The intravenous secretin test is widely used to distinguish gastrinoma (Zollinger-Ellison syndrome) from other causes of fasting hypergastrinemia. We report 2 patients with fasting hypergastrinemia and a rise of greater than 200 pg/ml in serum gastrin concentration after intravenous injection of 2 CU/kg body wt of pure natural secretin. Both patients had pentagastrin-fast achlorhydria. Thus, the intravenous secretin test may be positive in patients with achlorhydria-related hypergastrinemia. Gastric acid secretion should be measured in hypergastrinemic patients before embarking on a secretin test.
静脉注射促胰液素试验被广泛用于鉴别胃泌素瘤（卓-艾综合征）与其他导致空腹高胃泌素血症的病因。我们报告了2例空腹高胃泌素血症患者，静脉注射2 CU/kg体重的纯天然促胰液素后，血清胃泌素浓度升高超过200 pg/ml。两名患者均有五肽胃泌素激发无胃酸分泌。因此，静脉注射促胰液素试验在与无胃酸相关的高胃泌素血症患者中可能呈阳性。在进行促胰液素试验之前，应检测高胃泌素血症患者的胃酸分泌情况。
