Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
Chem Commun (Camb). 2021 Jul 13;57(56):6867-6870. doi: 10.1039/d1cc02683f.
Structurally diverse aryl chlorides were silylated with sodium silylsilanolate reagents in the presence of a Ni(cod)2 catalyst complexed with a phosphine ligand; PMe2Ph for electron-rich substrates, and PCy2Ph for electron-deficient ones. The mild reaction conditions allowed the silylation of various aryl chlorides including functionalised drug molecules.
结构多样的芳基氯化物在镍（cod）2 催化剂配合膦配体的存在下，与硅酸钠试剂反应，被硅烷基化；对于富电子底物，使用 PMe2Ph；对于缺电子底物，使用 PCy2Ph。温和的反应条件允许各种芳基氯化物的硅烷基化，包括功能化的药物分子。
