Schiano di Cola Francesca, Caratozzolo Salvatore, Di Cesare Marco, Liberini Paolo, Rao Renata, Padovani Alessandro
Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Pain Med. 2021 Nov 26;22(11):2728-2738. doi: 10.1093/pm/pnab202.
Aim of the present observational study was to assess the impact of coronavirus disease 2019 (COVID-19) quarantine on migraine and evaluate potential influencing factors. Previous studies reported mixed results regarding clinical outcome during quarantine in patients with migraine. In particular, data from areas strongly affected by COVID-19 pandemic are missing.
One hundred and seventy patients, previously assessed at the Headache Centre-ASST Spedali Civili Brescia, underwent a telephonic interview regarding migraine features and clinical, occupational, and lifestyle variables.
Compared to baseline, during quarantine, we found a significant overall reduction in migraine days (14.7 ± 0.6 vs 12.3 ± 0.7, P < .001), with 47.1% patients reporting a clinical improvement. Outdoor living spaces (odds ratio [OR] 2.3, 95% confidence interval [CI] 1.7-3.07, P = .009), a positive attitude throughout quarantine (OR 4.12, 95% CI 2.3-7.1, P = 0.03), working full-time (OR 1.03, 95% CI 0.5-1.9, P < .001) and a baseline diagnosis of chronic migraine (OR 1.4, 95% CI 1.1-2.02, P = 0.002) were associated with an increased chance of migraine improvement. Being single (OR 1.5, 95% CI 1.1-2.01, P = .05) and physical inactivity (OR 1.3, 95% CI 1.1-1.6, P = .02) were associated with an increased risk of worsening.
Quarantine had an overall positive impact on migraine. Based on our results, we hypothesize the reduction of daily hassles and challenges might be the main reason for such improvement.
本观察性研究旨在评估2019冠状病毒病（COVID-19）隔离对偏头痛的影响，并评估潜在影响因素。先前的研究报告了偏头痛患者隔离期间临床结果的混合结果。特别是，来自受COVID-19大流行严重影响地区的数据缺失。
170名先前在布雷西亚市立医院头痛中心接受评估的患者接受了关于偏头痛特征以及临床、职业和生活方式变量的电话访谈。
与基线相比，在隔离期间，我们发现偏头痛天数总体显著减少（14.7±0.6天对12.3±0.7天，P<0.001），47.1%的患者报告临床症状改善。户外生活空间（优势比[OR]2.3，95%置信区间[CI]1.7-3.07，P=0.009）、整个隔离期间的积极态度（OR 4.12，95%CI 2.3-7.1，P=0.03）、全职工作（OR 1.03，95%CI 0.5-1.9，P<0.001）以及慢性偏头痛的基线诊断（OR 1.4，95%CI 1.1-2.02，P=0.002）与偏头痛改善几率增加相关。单身（OR 1.5，95%CI 1.1-2.01，P=0.05）和缺乏身体活动（OR 1.3，95%CI 1.1-1.6，P=0.02）与病情恶化风险增加相关。
隔离对偏头痛总体上有积极影响。根据我们的结果，我们推测日常麻烦和挑战的减少可能是这种改善的主要原因。
