HIV-1 复制能力储备大小的免疫相关性。
Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size.
机构信息
Division of Medical Virology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town,South Africa.
出版信息
Clin Infect Dis. 2021 Oct 20;73(8):1528-1531. doi: 10.1093/cid/ciab587.
Abstract
Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. We measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8+ T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.
摘要
了解哪些因素影响潜伏的人类免疫缺陷病毒 1 型（HIV-1）储存库，对于开发治愈策略至关重要。我们测量了慢性感染期间开始进行抑制性抗逆转录病毒治疗 5 年后持续性 HIV-1 感染的频率。治疗前 CD8+T 细胞激活、CD4 计数最低点和 CD4:CD8 比值可预测储存库大小。
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