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人类免疫缺陷病毒 DNA 水平在开始抗逆转录病毒治疗之前确定，并与 CD8 T 细胞激活和记忆扩展有关。

Levels of Human Immunodeficiency Virus DNA Are Determined Before ART Initiation and Linked to CD8 T-Cell Activation and Memory Expansion.

机构信息

Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.

出版信息

J Infect Dis. 2020 Mar 16;221(7):1135-1145. doi: 10.1093/infdis/jiz563.

DOI:10.1093/infdis/jiz563
PMID:31776569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7075410/
Abstract

Initiation of antiretroviral therapy (ART) in early compared with chronic human immunodeficiency virus (HIV) infection is associated with a smaller HIV reservoir. This longitudinal analysis of 60 individuals who began ART during primary HIV infection (PHI) investigates which pre- and posttherapy factors best predict HIV DNA levels (a correlate of reservoir size) after treatment initiation during PHI. The best predictor of HIV DNA at 1 year was pre-ART HIV DNA, which was in turn significantly associated with CD8 memory T-cell differentiation (effector memory, naive, and T-bet-Eomes- subsets), CD8 T-cell activation (CD38 expression) and T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) expression on memory T cells. No associations were found for any immunological variables after 1 year of ART. Levels of HIV DNA are determined around the time of ART initiation in individuals treated during PHI. CD8 T-cell activation and memory expansion are linked to HIV DNA levels, suggesting the importance of the initial host-viral interplay in eventual reservoir size.

摘要

在早期开始抗逆转录病毒治疗 (ART) 与慢性人类免疫缺陷病毒 (HIV) 感染相比，与较小的 HIV 储存库相关。这项对 60 名在原发性 HIV 感染 (PHI) 期间开始接受 ART 的个体进行的纵向分析，研究了在 PHI 期间开始治疗后，哪些治疗前和治疗后因素能最好地预测 HIV DNA 水平（储存库大小的相关指标）。治疗前 HIV DNA 是预测治疗 1 年后 HIV DNA 的最佳指标，而 HIV DNA 又与 CD8 记忆 T 细胞分化（效应记忆、幼稚和 T-bet-Eomes-亚群）、CD8 T 细胞激活（CD38 表达）和 T 细胞免疫球蛋白和粘蛋白结构域包含-3（Tim-3）表达显著相关。在接受 ART 治疗 1 年后，没有发现任何免疫变量与 HIV DNA 水平相关。在 PHI 期间接受治疗的个体，在开始接受 ART 治疗时，HIV DNA 水平就已确定。CD8 T 细胞激活和记忆细胞扩增与 HIV DNA 水平相关，这表明初始宿主-病毒相互作用对最终储存库大小的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f00/7075410/b3bdaac056b9/jiz563f0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f00/7075410/059499d21eaa/jiz563f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f00/7075410/b3bdaac056b9/jiz563f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f00/7075410/90c2df58472f/jiz563f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f00/7075410/39033e4bb88c/jiz563f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f00/7075410/ce2b850fbf30/jiz563f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f00/7075410/059499d21eaa/jiz563f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f00/7075410/b3bdaac056b9/jiz563f0005.jpg

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