Castel Baptiste, Fairhead Sebastian, Furzer Oliver J, Redkar Amey, Wang Shanshan, Cevik Volkan, Holub Eric B, Jones Jonathan D G
The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, NR4 7UH, Norwich, United Kingdom.
Department of Biological Sciences, National University of Singapore, Singapore.
Plant J. 2021 Sep;107(5):1490-1502. doi: 10.1111/tpj.15396. Epub 2021 Aug 3.
The oomycete Albugo candida causes white rust of Brassicaceae, including vegetable and oilseed crops, and wild relatives such as Arabidopsis thaliana. Novel White Rust Resistance (WRR) genes from Arabidopsis enable new insights into plant/parasite co-evolution. WRR4A from Arabidopsis accession Columbia (Col-0) provides resistance to many but not all white rust races, and encodes a nucleotide-binding, leucine-rich repeat immune receptor. Col-0 WRR4A resistance is broken by AcEx1, an isolate of A. candida. We identified an allele of WRR4A in Arabidopsis accession Øystese-0 (Oy-0) and other accessions that confers full resistance to AcEx1. WRR4A carries a C-terminal extension required for recognition of AcEx1, but reduces recognition of several effectors recognized by the WRR4A allele. WRR4A confers full resistance to AcEx1 when expressed in the oilseed crop Camelina sativa.
卵菌纲的白锈菌会引发十字花科植物的白锈病，这些植物包括蔬菜作物、油料作物以及拟南芥等野生近缘种。来自拟南芥的新型抗白锈病（WRR）基因有助于深入了解植物与寄生虫的共同进化。拟南芥哥伦比亚生态型（Col-0）中的WRR4A对许多但并非所有白锈菌小种具有抗性，它编码一种核苷酸结合、富含亮氨酸重复序列的免疫受体。Col-0的WRR4A抗性会被白锈菌的一个分离株AcEx1打破。我们在拟南芥Øystese-0生态型（Oy-0）及其他生态型中鉴定出了一个WRR4A等位基因，该等位基因对AcEx1具有完全抗性。WRR4A带有一个识别AcEx1所需的C末端延伸，但会降低对WRR4A等位基因所识别的几种效应子的识别能力。当在油料作物亚麻荠中表达时，WRR4A对AcEx1具有完全抗性。
