Laboratory of Plant Virology, National Institute of Plant Genome Researchgrid.419632.b, New Delhi, India.
Department of Plant Sciences, University of Hyderabad, Telangana, India.
J Virol. 2022 Mar 9;96(5):e0208421. doi: 10.1128/jvi.02084-21. Epub 2022 Jan 5.
The Sw5 gene cluster furnishes robust resistance to in tomato, which has led to its widespread applicability in agriculture. Among the five orthologs, Sw5b functions as a resistance gene against a broad-spectrum tospovirus and is linked with tospovirus resistance. However, its paralog Sw5a has been recently implicated in providing resistance against , broadening the relevance of the Sw5 gene cluster in promoting defense against plant viruses. We propose that plants have established modifications within the homologs of R genes that permit identification of different effector proteins and provide broad and robust resistance against different pathogens through activation of the hypersensitive response and cell death.
Sw5 基因簇为番茄提供了对 的强大抗性，这使其在农业中得到了广泛应用。在这五个直系同源物中，Sw5b 作为广谱的 Tospovirus 的抗性基因发挥作用，并与 Tospovirus 抗性相关。然而，其旁系同源物 Sw5a 最近被牵涉到提供对 的抗性，拓宽了 Sw5 基因簇在促进植物病毒防御方面的相关性。我们提出，植物在 R 基因的同源物中建立了修饰，允许识别不同的效应蛋白，并通过激活过敏反应和细胞死亡，提供对不同病原体的广泛和强大的抗性。
