Department of Surgery, Ellis Fischel Cancer Center, USA; Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, USA.
Department of Surgery, Ellis Fischel Cancer Center, USA.
Semin Cancer Biol. 2022 Aug;83:377-383. doi: 10.1016/j.semcancer.2021.06.022. Epub 2021 Jun 26.
The epigenetic regulation of immune response involves reversible and heritable changes that do not alter the DNA sequence. Though there have been extensive studies accomplished relating to epigenetic changes in cancer cells, recent focus has been shifted on epigenetic-mediated changes in the immune cells including T cells, Macrophages, Natural Killer cells and anti-tumor immune responses. This review compiles the most relevant and recent literature related to the role of epigenetic mechanisms including DNA methylation and histone modifications in immune cells of wide range of cancers. We also include recent research with respect to role of the most relevant transcription factors that epigenetically control the anti-tumor immune response. Finally, a statement of future direction that promises to look forward for strategies to improve immunotherapy in cancer.
免疫反应的表观遗传调控涉及可逆和可遗传的变化，不会改变 DNA 序列。尽管已经完成了大量与癌细胞表观遗传变化相关的研究，但最近的重点已转移到免疫细胞（包括 T 细胞、巨噬细胞、自然杀伤细胞和抗肿瘤免疫反应）的表观遗传介导变化上。本综述汇集了与包括 DNA 甲基化和组蛋白修饰在内的表观遗传机制在广泛癌症的免疫细胞中的作用相关的最相关和最新文献。我们还包括了关于最相关转录因子的最新研究，这些转录因子通过表观遗传控制抗肿瘤免疫反应。最后，对未来方向的陈述有望为改善癌症免疫疗法的策略提供展望。
