School of Medicine, Guizhou University, Guiyang, China.
Department of Gastrointestinal Surgery, Guizhou Provincial People's Hospital, Guiyang, China.
Front Immunol. 2023 Jan 11;13:1099892. doi: 10.3389/fimmu.2022.1099892. eCollection 2022.
Epigenetic modifications may alter the proliferation and differentiation of normal cells, leading to malignant transformation. They can also affect normal stimulation, activation, and abnormal function of immune cells in the tissue microenvironment. Histone methylation, coordinated by histone methylase and histone demethylase to stabilize transcription levels in the promoter area, is one of the most common types of epigenetic alteration, which gained increasing interest. It can modify gene transcription through chromatin structure and affect cell fate, at the transcriptome or protein level. According to recent research, histone methylation modification can regulate tumor and immune cells affecting anti-tumor immune response. Consequently, it is critical to have a thorough grasp of the role of methylation function in cancer treatment. In this review, we discussed recent data on the mechanisms of histone methylation on factors associated with immune resistance of tumor cells and regulation of immune cell function.
表观遗传修饰可能改变正常细胞的增殖和分化，导致恶性转化。它们还可能影响组织微环境中免疫细胞的正常刺激、激活和异常功能。组蛋白甲基化由组蛋白甲基转移酶和组蛋白去甲基酶协调，以稳定启动子区域的转录水平，是最常见的表观遗传改变类型之一，越来越受到关注。它可以通过染色质结构修饰基因转录，并在转录组或蛋白质水平上影响细胞命运。根据最近的研究，组蛋白甲基化修饰可以调节肿瘤和免疫细胞，影响抗肿瘤免疫反应。因此，深入了解甲基化功能在癌症治疗中的作用至关重要。在这篇综述中，我们讨论了组蛋白甲基化对与肿瘤细胞免疫抵抗相关因素的作用以及对免疫细胞功能的调节的最新数据。
