International Research Center for Marine Biosciences at Shanghai Ocean University, Ministry of Science and Technology, Shanghai Ocean University, Shanghai 201306, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding, Shanghai Ocean University, China.
International Research Center for Marine Biosciences at Shanghai Ocean University, Ministry of Science and Technology, Shanghai Ocean University, Shanghai 201306, China; Key Laboratory of Marine Ecosystem Dynamics, Second Institute of Oceanography, Ministry of Natural Resources, Hangzhou 310012, China; State Key Laboratory of Satellite Ocean Environment Dynamics, Second Institute of Oceanography, Ministry of Natural Resources, Hangzhou 310012, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding, Shanghai Ocean University, China.
Mar Pollut Bull. 2021 Sep;170:112661. doi: 10.1016/j.marpolbul.2021.112661. Epub 2021 Jun 25.
There are many toxicological studies on microplastics, but little is known about the effect of nanoplastics (NPs). Here, we evaluated the oxidative stress responses induced by NPs (10, 10 and 10 particles/l) in juvenile Larimichthys crocea during 14-d NPs exposure followed by a 7-d recovery. After exposure, the activities of antioxidant enzymes (SOD, CAT, GPx) and MDA levels increased in the liver of fish at the highest NPs concentration. SOD and CAT activities remained elevated above the baseline after recovery under high-concentration NPs but returned to the baseline in two other NP treatments. Although lipid peroxidation in liver was reversible, juvenile fish in NPs treatments exhibited a lower survival rate than the control during both exposure and recovery. Furthermore, IBR value and PCA analysis showed the potential adverse effects of NPs. Considering that NPs can reduce the survival of fish juveniles, impacts of NPs on fishery productivity should be considered.
已有许多关于微塑料的毒理学研究，但纳米塑料（NPs）的影响却知之甚少。在这里，我们评估了 NPs（10、10 和 10 个/升）在幼龄大黄鱼中诱导的氧化应激反应，随后进行了 14 天的 NPs 暴露和 7 天的恢复期。暴露后，最高 NPs 浓度下鱼肝脏中的抗氧化酶（SOD、CAT、GPx）活性和 MDA 水平升高。在高浓度 NPs 下恢复后，SOD 和 CAT 活性仍高于基线，但在另外两种 NP 处理中恢复到基线。尽管肝脏中的脂质过氧化是可逆的，但在暴露和恢复期间，NPs 处理组的幼鱼存活率均低于对照组。此外，IBR 值和 PCA 分析显示了 NPs 的潜在不利影响。考虑到 NPs 会降低鱼类幼体的存活率，应该考虑 NPs 对渔业生产力的影响。
