与慢性肝脏疾病患者纵向生活质量变化相关的因素。
Factors Associated With Longitudinal QOL Change in Patients With Chronic Liver Diseases.
机构信息
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Japan;
Center for Clinical Research and Education, Hyogo College of Medicine, Nishinomiya, Japan.
出版信息
In Vivo. 2021 Jul-Aug;35(4):2451-2456. doi: 10.21873/invivo.12524.
AIM
To examine the relationship between longitudinal quality of life (QOL) change, as assessed by the 36-Item Short Form Health Survey (SF-36), sarcopenia-related factors and body composition in patients with chronic liver diseases (CLDs).
PATIENTS AND METHODS
Data from patients with CLDs (n=184) were retrospectively analyzed, focusing on factors associated with the difference of physical and mental component summary score (PCS and MCS) in SF-36 between the two visits (Δ and Δ). The difference of serum albumin level, body mass index (BMI), arm circumference, arm muscle circumference, grip strength (GS), skeletal muscle index, extracellular to total body water ratio between the two visits were included into the multiple regression analysis.
RESULTS
Δ (p=0.0325) and Δ (p<0.0001) were independent factors linked to Δ Δ (p=0.0005) and Δ (p=0.0232) were independent factors linked to Δ Conclusion: Significance of serum albumin level, muscle strength and body composition on health-related QOL in CLD patients should be emphasized.
目的
通过 36 项简短健康调查问卷（SF-36）评估慢性肝病（CLD）患者的纵向生活质量（QOL）变化与肌少症相关因素和身体成分之间的关系。
患者与方法
回顾性分析了 184 例 CLD 患者的数据，重点分析了 SF-36 中两次就诊时（Δ和Δ）的身体和心理成分综合评分（PCS 和 MCS）差异相关因素。将两次就诊时的血清白蛋白水平、体重指数（BMI）、臂围、臂肌围、握力（GS）、骨骼肌指数、细胞外与总体水比值的差异纳入多元回归分析。
结果
Δ（p=0.0325）和Δ（p<0.0001）是与 Δ（p=0.0005）和Δ（p=0.0232）相关的独立因素。
结论
应重视血清白蛋白水平、肌肉力量和身体成分对 CLD 患者健康相关 QOL 的意义。
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