慢性肝病患者的健康相关生活质量：握力的显著影响。
Health-Related Quality of Life in Chronic Liver Diseases: A Strong Impact of Hand Grip Strength.
作者信息
Nishikawa Hiroki, Enomoto Hirayuki, Yoh Kazunori, Iwata Yoshinori, Sakai Yoshiyuki, Kishino Kyohei, Ikeda Naoto, Takashima Tomoyuki, Aizawa Nobuhiro, Takata Ryo, Hasegawa Kunihiro, Ishii Noriko, Yuri Yukihisa, Nishimura Takashi, Iijima Hiroko, Nishiguchi Shuhei
机构信息
Division of Hepatobiliary and Pancreatic disease, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Nishinomiya 663-8501, Japan.
出版信息
J Clin Med. 2018 Dec 15;7(12):553. doi: 10.3390/jcm7120553.
We sought to examine the influence of hand grip strength (HGS) and skeletal muscle mass (SMM) on the health-related quality of life (H-QOL) as evaluated by the 36-Item Short-Form Health Survey (SF-36) questionnaire in chronic liver diseases (CLDs, 198 men and 191 women). Decreased HGS was defined as HGS <26 kg for men and <18 kg for women. Decreased SMM was defined as SMM index <7.0 kg/m² for men and <5.7 kg/m² for women, using bioimpedance analysis. SF-36 scores were compared between groups stratified by HGS or SMM. Between-group differences (decreased HGS vs. non-decreased HGS) in the items of physical functioning (PF), role physical (RP), bodily pain, vitality (VT), social functioning (SF), role emotional (RE), and physical component summary score (PCS) reached significance, while between-group differences (decreased SMM vs. non-decreased SMM) in the items of PF, SF and RE were significant. Multivariate analyses revealed that HGS was significantly linked to PF ( = 0.0031), RP ( = 0.0185), and PCS ( = 0.0421) in males, and PF ( = 0.0034), VT ( = 0.0150), RE ( = 0.0422), and PCS ( = 0.0191) in females. HGS had a strong influence especially in the physiological domains in SF-36 in CLDs.
我们试图通过36项简明健康调查问卷（SF-36）来评估握力（HGS）和骨骼肌质量（SMM）对慢性肝病（CLDs，198名男性和191名女性）患者健康相关生活质量（H-QOL）的影响。男性HGS<26kg、女性HGS<18kg被定义为握力下降。采用生物电阻抗分析法，男性SMM指数<7.0kg/m²、女性SMM指数<5.7kg/m²被定义为骨骼肌质量下降。比较了根据HGS或SMM分层的各组之间的SF-36评分。身体功能（PF）、身体角色（RP）、身体疼痛、活力（VT）、社会功能（SF）、情感角色（RE）和身体综合评分（PCS）项目在握力下降组与未下降组之间的组间差异具有统计学意义，而PF、SF和RE项目在骨骼肌质量下降组与未下降组之间的组间差异具有统计学意义。多因素分析显示，男性中HGS与PF（=0.0031）、RP（ =0.0185）和PCS（ =0.0421）显著相关，女性中HGS与PF（ =0.0034）、VT（ =0.0150）、RE（ =0.0422）和PCS（ =0.0191）显著相关。在慢性肝病患者中，HGS对SF-36的生理领域影响尤其显著。
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