Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Pathology, National Cancer Center, Goyang-si, Republic of Korea;
In Vivo. 2021 Jul-Aug;35(4):2469-2481. doi: 10.21873/invivo.12527.
BACKGROUND/AIM: Some metastatic tumors that involve the fallopian tube show intraepithelial spread, mimicking primary tubal neoplasm and representing a potential diagnostic pitfall. In this study, we aimed to investigate the clinicopathological characteristics of tubal intraepithelial metastasis (IEM) from cervical carcinoma.
We analyzed the clinical features, histological features, and immunophenotypes of IEMs in five patients with cervical carcinoma.
This study included usual-type (1/5), mucinous-type (1/5), and gastric-type (2/5) endocervical adenocarcinomas and small cell neuroendocrine carcinoma (1/5) cases. None of the patients had ovarian metastasis, but metastatic tumor cells spread along the tubal mucosal surface and partially replaced the lining epithelium. Histological features of metastatic tumors closely resembled those of the primary tumors in all cases.
Tubal IEM can mimic various tubal lesions including serous tubal intraepithelial carcinoma. Morphological consistency between the primary and metastatic tumors and immunostaining help guide the differential diagnosis of challenging intraepithelial lesions of the fallopian tube.
背景/目的：一些累及输卵管的转移性肿瘤表现为上皮内播散，类似于原发性输卵管肿瘤，这是潜在的诊断陷阱。本研究旨在探讨来源于宫颈癌的输卵管上皮内转移（IEM）的临床病理特征。
我们分析了 5 例宫颈癌患者的 IEM 的临床特征、组织学特征和免疫表型。
本研究包括普通型（1/5）、黏液型（1/5）和胃型（2/5）宫颈腺癌以及小细胞神经内分泌癌（1/5）。所有患者均无卵巢转移，但转移瘤细胞沿输卵管黏膜表面播散并部分取代衬里上皮。在所有病例中，转移瘤的组织学特征均与原发性肿瘤非常相似。
输卵管 IEM 可模拟多种输卵管病变，包括浆液性输卵管上皮内癌。原发肿瘤和转移肿瘤之间的形态一致性以及免疫组化有助于指导输卵管上皮内病变的鉴别诊断。
