Zhong Weina, Benissan-Messan Dathe Z, Ma Jianjie, Cai Chuanxi, Lee Peter H U
Department of Surgery, The Ohio State University, Columbus, OH, USA.
Department of Pathology and Laboratory Medicine, Brown University, Campus Box G-E5, 70 Ship Street, Providence, RI, 02912, USA.
Cell Biosci. 2021 Jun 28;11(1):115. doi: 10.1186/s13578-021-00629-x.
Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention. Mitsugumin 53 (MG53), also known as TRIM72, is a TRIM family protein that was found to be involved in cell membrane repair and primarily found in striated muscle. Its role in skeletal muscle regeneration and myogenesis has been well documented. However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. This review summarizes the regulatory role of MG53 in cardiac tissues, current debates regarding MG53 in diabetes and diabetic cardiomyopathy, as well as highlights potential clinical applications of MG53 in treating cardiac pathologies.
心脏病仍是全球首要死因，因此需要进一步研究以确定其潜在机制以及治疗和预防的潜在靶点。 Mitsugumin 53（MG53），也称为TRIM72，是一种TRIM家族蛋白，被发现参与细胞膜修复，主要存在于横纹肌中。它在骨骼肌再生和肌生成中的作用已有充分记载。然而，越来越多的证据表明，MG53在心脏组织中具有潜在的保护作用，包括在心脏缺血/再灌注损伤、心肌细胞膜损伤修复和心房纤维化中。本综述总结了MG53在心脏组织中的调节作用、目前关于MG53在糖尿病和糖尿病性心肌病方面的争议，以及MG53在治疗心脏疾病中的潜在临床应用。
