Bickle John
Department of Philosophy, Mississippi State University; Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center. USA.
AIMS Neurosci. 2021 Feb 22;8(3):322-339. doi: 10.3934/Neuroscience.2021017. eCollection 2021.
I recount some landmark discoveries that initially confirmed the cyclic AMP response element-binding (CREB) protein-memory consolidation and allocation linkages. This work constitutes one of the successes of the field of Molecular and Cellular Cognition (MCC) but is also of interest to philosophers of neuroscience. Two approaches, "mechanism" and "ruthless reductionism", claim to account for this case, yet these accounts differ in one crucial way. I explain this difference and argue that both the experiment designs and discussions of these discoveries by MCC scientists better fit the ruthless reductionist's account. This conclusion leads to further philosophical discussion about how discoveries in cellular/molecular neurobiology integrate with systems neuroscience findings.
我讲述了一些具有里程碑意义的发现，这些发现最初证实了环磷酸腺苷反应元件结合（CREB）蛋白与记忆巩固及分配之间的联系。这项工作是分子与细胞认知（MCC）领域的成功之一，但神经科学哲学家也对此感兴趣。“机制”和“无情还原论”这两种方法都声称可以解释这一案例，但这些解释在一个关键方面存在差异。我解释了这种差异，并认为MCC科学家对这些发现的实验设计和讨论更符合无情还原论者的解释。这一结论引发了关于细胞/分子神经生物学中的发现如何与系统神经科学的研究结果相结合的进一步哲学讨论。
