Han Jin-Hee, Kushner Steven A, Yiu Adelaide P, Cole Christy J, Matynia Anna, Brown Robert A, Neve Rachael L, Guzowski John F, Silva Alcino J, Josselyn Sheena A
Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Science. 2007 Apr 20;316(5823):457-60. doi: 10.1126/science.1139438.
Competition between neurons is necessary for refining neural circuits during development and may be important for selecting the neurons that participate in encoding memories in the adult brain. To examine neuronal competition during memory formation, we conducted experiments with mice in which we manipulated the function of CREB (adenosine 3',5'-monophosphate response element-binding protein) in subsets of neurons. Changes in CREB function influenced the probability that individual lateral amygdala neurons were recruited into a fear memory trace. Our results suggest a competitive model underlying memory formation, in which eligible neurons are selected to participate in amemorytrace as a function of their relative CREB activity at the time of learning.
神经元之间的竞争对于在发育过程中优化神经回路是必要的，并且对于选择参与成人大脑记忆编码的神经元可能也很重要。为了研究记忆形成过程中的神经元竞争，我们用小鼠进行了实验，在实验中我们操纵了神经元亚群中CREB（环磷腺苷反应元件结合蛋白）的功能。CREB功能的变化影响了单个杏仁核外侧神经元被纳入恐惧记忆痕迹的概率。我们的结果表明了一种记忆形成的竞争模型，其中符合条件的神经元根据它们在学习时的相对CREB活性被选择参与记忆痕迹。
