Department of Cardiothoracic Surgery, Nantong Third People's Hospital, Nantong University, Nantong, Jiangsu 226006, P.R. China.
Department of Internal Medicine, Medical School of Nantong University, Nantong, Jiangsu 226006, P.R. China.
Oncol Rep. 2021 Aug;46(2). doi: 10.3892/or.2021.8123. Epub 2021 Jun 29.
Lung cancer is the most common malignant tumor type and it is associated with poor prognosis. The identification of potential biomarkers is of great significance for the early diagnosis and treatment of lung cancer. Non‑small cell lung cancer (NSCLC) is the most common pathological type of lung cancer. The present study aimed to investigate the mechanism via which thyroid hormone receptor‑interacting protein 13 (TRIP13) participates in the malignant progression of NSCLC. Immunohistochemistry, reverse transcription‑quantitative PCR and western blotting were used to assess the expression level of TRIP13. According to The Cancer Genome Atlas database, TRIP13 was upregulated in NSCLC tissues compared with adjacent normal tissues. Moreover, TRIP13 knockdown increased apoptosis, induced cell cycle arrest in the S phase and inhibited the proliferation, invasion and migration of H1299 cells . Furthermore, TRIP13 upregulation was closely associated with tumor metastasis via epithelial‑mesenchymal transformation. In conclusion, TRIP13 could promote the malignant progression of lung cancer, and TRIP13 may be a potential biomarker for the early diagnosis and treatment of NSCLC.
肺癌是最常见的恶性肿瘤类型，预后不良。鉴定潜在的生物标志物对于肺癌的早期诊断和治疗具有重要意义。非小细胞肺癌（NSCLC）是肺癌最常见的病理类型。本研究旨在探讨甲状腺激素受体相互作用蛋白 13（TRIP13）参与 NSCLC 恶性进展的机制。免疫组织化学、逆转录-定量 PCR 和 Western blot 用于评估 TRIP13 的表达水平。根据癌症基因组图谱数据库，与相邻正常组织相比，TRIP13 在 NSCLC 组织中上调。此外，TRIP13 敲低增加了细胞凋亡，诱导 H1299 细胞周期停滞在 S 期，并抑制了细胞增殖、侵袭和迁移。此外，TRIP13 的上调通过上皮-间充质转化与肿瘤转移密切相关。总之，TRIP13 可促进肺癌的恶性进展，TRIP13 可能是 NSCLC 早期诊断和治疗的潜在生物标志物。
