Center for Health Sciences and Sports, Adapted Physical Activity Laboratory, Santa Catarina State University, Florianópolis, Santa Catarina 88080‑350, Brazil.
Pharmaceutical Sciences Department, Federal University of Santa Catarina, Florianópolis, Santa Catarina 88010‑970, Brazil.
Mol Med Rep. 2021 Aug;24(2). doi: 10.3892/mmr.2021.12257. Epub 2021 Jun 29.
There is a consensus regarding the efficacy of physical exercise in maintaining or improving human health; however, there are few studies examining the effect of physical exercise on the expression levels of microRNAs (miRNA/miRs) in Parkinson's disease (PD). The aim of the present study was to investigate the effects of an interval training program on a cycle ergometer on the expression levels of miR‑106a‑5p, miR‑103a‑3p and miR‑29a‑3p in serum samples from men with PD. This was a quasi‑experimental study with pre‑ and post‑testing and with a non‑equivalent group design. The participants were selected based on the eligibility criteria and subsequently classified into two groups: Experimental group and control group. The evaluations were performed at the beginning of the study (week 0) and after 8 weeks of the intervention program (week 9). The interval training program was performed on a cycle ergometer for 30 min, three times a week during an 8‑week period. The expression levels of miR‑106a‑5p, miR‑103a‑3p and miR‑29a‑3p in the experimental group were increased after physical exercise and were associated with cognitive improvement in men with PD. However, further studies are required to clarify the potential use of these circulating miRNAs as markers of adaptation to physical exercise. Collectively, the present results indicated that these three miRNAs may be associated with the exercise response and cognitive improvement in men with PD.
关于运动对人类健康的维护或改善的效果已经达成共识；然而，很少有研究探讨运动对帕金森病（PD）患者中 microRNAs（miRNA/miRs）表达水平的影响。本研究旨在探究间歇训练方案对 PD 男性血清样本中 miR-106a-5p、miR-103a-3p 和 miR-29a-3p 表达水平的影响。这是一项具有预测试和后测试的准实验研究，采用非等效组设计。参与者根据入选标准选择，并随后分为两组：实验组和对照组。评估在研究开始时（第 0 周）和干预方案 8 周后（第 9 周）进行。在 8 周期间，每周三次，每次 30 分钟，在功率自行车上进行间歇训练。实验组的 miR-106a-5p、miR-103a-3p 和 miR-29a-3p 表达水平在运动后增加，并与 PD 男性的认知改善相关。然而，需要进一步的研究来阐明这些循环 miRNA 作为对运动适应的标志物的潜在用途。总之，本研究结果表明，这三种 miRNA 可能与 PD 男性的运动反应和认知改善相关。
